Fractional carbon dioxide laser assisted delivery of tranexamic acid versus ascorbic acid in the treatment of melasma: a split face comparative study with digital skin analysis.
controlled
EVIDENCE COMPARISON
DirectionalVitamin C (L-Ascorbic Acid)
vs Tranexamic Acid
for Redness Reduction
Early or indirect evidence suggests vitamin C may reduce skin tone-related redness 1.78 times more effectively than tranexamic acid.
1.78x
Effect ratio
Vitamin C (L-Ascorbic Acid)
Favored
1
Study
Direct
Comparison
ExploratorySubjective endpointTone
Limits: Includes subjective endpoint · Early-stage evidence tier
How to read this claim
Kept public as exploratory because it includes subjective endpoint; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.