Topical 5% tranexamic acid for the treatment of melasma in Asians: a double-blind randomized controlled clinical trial.
randomized, double-blind
EVIDENCE COMPARISON
DirectionalTrifarotene
vs Tranexamic Acid
for Redness Reduction
Early or indirect evidence suggests tranexamic acid may reduce skin redness 1.27 times more effectively than trifarotene for improving tone, based on indirect comparison.
1.27x
Effect ratio
Tranexamic Acid
Favored
2
Studies
Indirect
Comparison
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
Tone
How to read this claim
Kept public as exploratory because it indirect comparison; includes estimated measurement; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.