Comparative efficacy of topical tofacitinib versus topical tacrolimus in the treatment of localized vitiligo: a randomized investigator-blinded intraindividual trial
randomized, split-face
EVIDENCE COMPARISON
Gold StandardTofacitinib
vs Tacrolimus
for Pigmentation Reduction
Studies show tofacitinib reduces pigmentation 1.65 times more effectively than tacrolimus for improving skin tone evenness.
1.65x
Effect ratio
Tofacitinib
Favored
1
Study
Direct
Comparison
CoreSubjective endpointTone
Limits: Includes subjective endpoint
How to read this claim
Direct comparison with enough study context for public-facing comparative wording, with limits noted for includes subjective endpoint.
The published evidence does not currently show a major generalization warning beyond the listed study limits.