Efficacy and safety of calcipotriol as a potential topical treatment of acne vulgaris: a randomized, controlled, triple blinded, split-face clinical trial
randomized, split-face
EVIDENCE COMPARISON
DirectionalEarly or indirect evidence suggests trifarotene may improve pore refinement by 33% compared to no skincare treatment, based on indirect comparison.
Effect ratio
Favored
Studies
Comparison
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
Texture
Kept public as exploratory because it indirect comparison; includes subjective endpoint; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.