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EVIDENCE COMPARISON

Directional

No Skincare
vs Topical Methotrexate
for Redness Reduction

Early or indirect evidence suggests no skincare may reduce redness 1.5 times more effectively than topical methotrexate for skin tone, based on indirect comparison.

1.50x

Effect ratio

No Skincare

Favored

2

Studies

Indirect

Comparison

ExploratorySubjective endpointTone

Limits: Indirect comparison · Includes subjective endpoint · Early-stage evidence tier

This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.

How to read this claim

Kept public as exploratory because it indirect comparison; includes subjective endpoint; early-stage evidence tier.

Some study-specific context may affect how broadly this comparison generalizes.

Source Studies (2)

Efficacy and safety of calcipotriol as a potential topical treatment of acne vulgaris: a randomized, controlled, triple blinded, split-face clinical trial

randomized, split-face
DOI

Clinical, dermoscopic, and histopathologic evaluation of topical methotrexate 1% hydrogel versus topical Calcipotriol 0.005% cream in the treatment of plaque psoriasis.

controlled
DOIPubMed
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