Melasma update
randomized, double-blind, split-face
EVIDENCE COMPARISON
Gold StandardNo Skincare
vs Silymarin
for Pigmentation Reduction
Early or indirect evidence suggests silymarin reduces pigmentation 2.00x less effectively than no treatment for improving skin tone.
2.00x
Effect ratio
No Skincare
Favored
1
Study
Direct
Comparison
Tone
How to read this claim
Kept public as exploratory because it includes estimated measurement.
Some study-specific context may affect how broadly this comparison generalizes.