Antiaging efficacy of melatonin-based day and night creams: A randomized, split-face, assessor-blinded proof-of-concept trial
randomized, split-face
EVIDENCE COMPARISON
StrongEvidence suggests using no skincare provides 1.30x better elasticity improvement for firmness compared to melatonin-based products.
Effect ratio
Favored
Study
Comparison
Limits: Includes subjective endpoint
Direct comparison with enough study context for public-facing comparative wording, with limits noted for includes subjective endpoint.
The published evidence does not currently show a major generalization warning beyond the listed study limits.