Self‐applied topical interventions for melasma: a systematic review and meta‐analysis of data from randomized, investigator‐blinded clinical trials
randomized, split-face
EVIDENCE COMPARISON
StrongNo Skincare
vs Cysteamine
for Pigmentation Reduction
Evidence suggests no skincare produces 1.5 times better pigmentation reduction for tone than cysteamine based on strong evidence.
1.50x
Effect ratio
No Skincare
Favored
1
Study
Direct
Comparison
Tone
How to read this claim
Direct comparison with enough study context for public-facing comparative wording, with limits noted for includes subjective endpoint.
The published evidence does not currently show a major generalization warning beyond the listed study limits.