A Randomized, Double-Blind, Split-Face Study of Topical Silymarin vs 2% Hydroquinone Cream in Melasmas.
randomized, double-blind, split-face
EVIDENCE COMPARISON
SupportiveNiacinamide
vs Silymarin
for Pigmentation Reduction
Early or indirect evidence suggests silymarin may reduce pigmentation slightly more than niacinamide for improving skin tone, based on indirect comparison.
1.06x
Effect ratio
Silymarin
Favored
3
Studies
Indirect
Comparison
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
Tone
How to read this claim
Kept public as exploratory because it indirect comparison; mixed endpoint quality.
Some study-specific context may affect how broadly this comparison generalizes.
1 linked trialIngredient trial
Source Studies (3)
A Randomized, Double-Blind, Split-Face Study of Topical Silymarin vs 2% Hydroquinone Cream in Melasmas.
randomized, double-blind, split-face
… and efficacy of niosomal and conventional tranexamic acid/niacinamide vs. hydroquinone creams in melasma: A randomized, double-blind, case-controlled clinical …
randomized, double-blind