… and efficacy of niosomal and conventional tranexamic acid/niacinamide vs. hydroquinone creams in melasma: A randomized, double-blind, case-controlled clinical …
randomized, double-blind
EVIDENCE COMPARISON
DirectionalNiacinamide
vs Lignin Peroxidase
for Pigmentation Reduction
Early or indirect evidence suggests niacinamide and lignin peroxidase show equal effectiveness for improving skin tone through pigmentation reduction, based on indirect comparison.
1.00x
Effect ratio
Neither
Favored
2
Studies
Indirect
Comparison
ExploratoryTone
Limits: Indirect comparison · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.