A double-blind, placebo controlled clinical trial evaluating the efficacy and safety of a new skin whitening combination in patients with chloasma
double-blind, split-face
EVIDENCE COMPARISON
DirectionalNiacinamide
vs Hyaluronic Acid Matrix (HAm)
for Pigmentation Reduction
Early or indirect evidence suggests hyaluronic acid matrix may reduce pigmentation twice as effectively as niacinamide for improving skin tone, based on indirect comparison.
2.00x
Effect ratio
Hyaluronic Acid Matrix (HAm)
Favored
2
Studies
Indirect
Comparison
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
Tone
How to read this claim
Kept public as exploratory because it indirect comparison; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.
Source Studies (2)
… double-blind, placebo-controlled clinical trial evaluating the efficacy of a novel combination of hyaluronic acid serum and antioxidant cream for rejuvenation of the …
randomized, double-blind