A double-blind, placebo controlled clinical trial evaluating the efficacy and safety of a new skin whitening combination in patients with chloasma
double-blind, split-face
EVIDENCE COMPARISON
DirectionalNiacinamide
vs Epidermal Growth Factor (EGF)
for Pigmentation Reduction
Early or indirect evidence suggests niacinamide may reduce pigmentation nearly twice as effectively as epidermal growth factor for improving skin tone, based on indirect comparison.
1.87x
Effect ratio
Niacinamide
Favored
2
Studies
Indirect
Comparison
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
Tone
How to read this claim
Kept public as exploratory because it indirect comparison; mixed endpoint quality; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.
Source Studies (2)
A Randomized, Double-Blind, Placebo-Controlled, Split-Face Study of the Efficacy of Topical Epidermal Growth Factor for the Treatment of Melasma.
randomized, double-blind, split-face