Clinical, dermoscopic, and histopathologic evaluation of topical methotrexate 1% hydrogel versus topical Calcipotriol 0.005% cream in the treatment of plaque psoriasis.
controlled
EVIDENCE COMPARISON
DirectionalMethotrexate 1% Gel
vs Topical Methotrexate
for Redness Reduction
Early or indirect evidence suggests methotrexate 1% Gel may provide 3 times better redness reduction for skin tone than Topical Methotrexate, based on indirect comparison.
3.00x
Effect ratio
Methotrexate 1% Gel
Favored
2
Studies
Indirect
Comparison
ExploratorySubjective endpointTone
Limits: Indirect comparison · Includes subjective endpoint · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; includes subjective endpoint; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.