Efficacy and safety of calcipotriol as a potential topical treatment of acne vulgaris: a randomized, controlled, triple blinded, split-face clinical trial
randomized, split-face
EVIDENCE COMPARISON
DirectionalMethotrexate 1% Gel
vs No Skincare
for Redness Reduction
Early or indirect evidence suggests methotrexate 1% gel may reduce redness twice as effectively as no treatment for improving skin tone, based on indirect comparison.
2.00x
Effect ratio
Methotrexate 1% Gel
Favored
2
Studies
Indirect
Comparison
ExploratorySubjective endpointTone
Limits: Indirect comparison · Includes subjective endpoint · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; includes subjective endpoint; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.