Antiaging efficacy of melatonin-based day and night creams: A randomized, split-face, assessor-blinded proof-of-concept trial
randomized, split-face
EVIDENCE COMPARISON
DirectionalMelatonin
vs Trifarotene
for Surface Smoothness
Early or indirect evidence suggests trifarotene may improve skin surface smoothness 2.76 times more effectively than melatonin for texture enhancement, based on indirect comparison.
2.76x
Effect ratio
Trifarotene
Favored
1
Study
Indirect
Comparison
ExploratorySubjective endpointTexture
Limits: Indirect comparison · Includes subjective endpoint · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; includes subjective endpoint; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.