Antiaging efficacy of melatonin-based day and night creams: A randomized, split-face, assessor-blinded proof-of-concept trial
randomized, split-face
EVIDENCE COMPARISON
DirectionalMelatonin
vs Panthenol
for Hydration Retention
Early or indirect evidence suggests melatonin may provide 1.88 times better hydration retention than panthenol for skin moisture, based on indirect comparison.
1.88x
Effect ratio
Melatonin
Favored
2
Studies
Indirect
Comparison
ExploratoryMixed endpointsMoisture
Limits: Indirect comparison · Mixed endpoint quality · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; mixed endpoint quality; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.