Topical epidermal growth factor for the improvement of acne lesions: a randomized, double-blinded, placebo-controlled, split-face trial.
randomized, double-blind, split-face
EVIDENCE COMPARISON
DirectionalMelatonin
vs Epidermal Growth Factor (EGF)
for Hydration Retention
Early or indirect evidence suggests epidermal growth factor may provide 2.25 times better hydration retention than melatonin for skin moisture, based on indirect comparison.
2.25x
Effect ratio
Epidermal Growth Factor (EGF)
Favored
2
Studies
Indirect
Comparison
ExploratoryMixed endpointsMoisture
Limits: Indirect comparison · Mixed endpoint quality · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; mixed endpoint quality; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.