A Randomized, Double-Blind, Split-Face Study of Topical Silymarin vs 2% Hydroquinone Cream in Melasmas.
randomized, double-blind, split-face
EVIDENCE COMPARISON
SupportiveLotus Sprout Extract
vs Silymarin
for Pigmentation Reduction
Early or indirect evidence suggests lotus sprout extract may reduce pigmentation 1.70 times more effectively than silymarin for improving skin tone, based on indirect comparison.
1.70x
Effect ratio
Lotus Sprout Extract
Favored
3
Studies
Indirect
Comparison
ExploratoryMixed endpointsTone
Limits: Indirect comparison · Mixed endpoint quality
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; mixed endpoint quality.
Some study-specific context may affect how broadly this comparison generalizes.
1 linked trialIngredient trial
Source Studies (3)
A Randomized, Double-Blind, Split-Face Study of Topical Silymarin vs 2% Hydroquinone Cream in Melasmas.
randomized, double-blind, split-face
A randomized, controlled, split-face, double-blind comparison of a multimodality pigment-correcting serum containing lotus sprout extract versus hydroquinone for …
randomized, double-blind, split-face