A double-blind, placebo controlled clinical trial evaluating the efficacy and safety of a new skin whitening combination in patients with chloasma
double-blind, split-face
EVIDENCE COMPARISON
DirectionalLipo-hydroxy Acid
vs Silymarin
for Pigmentation Reduction
Early or indirect evidence suggests silymarin may reduce pigmentation 1.5 times more effectively than lipo-hydroxy acid for improving skin tone, based on indirect comparison.
1.50x
Effect ratio
Silymarin
Favored
2
Studies
Indirect
Comparison
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
Tone
How to read this claim
Kept public as exploratory because it indirect comparison; includes estimated measurement; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.
Source Studies (2)
Melasma update
randomized, double-blind, split-face