A double-blind, placebo controlled clinical trial evaluating the efficacy and safety of a new skin whitening combination in patients with chloasma
double-blind, split-face
EVIDENCE COMPARISON
DirectionalLipo-hydroxy Acid
vs Cysteamine
for Pigmentation Reduction
Early or indirect evidence suggests cysteamine may reduce pigmentation twice as effectively as lipo-hydroxy acid for improving skin tone, based on indirect comparison.
2.00x
Effect ratio
Cysteamine
Favored
2
Studies
Indirect
Comparison
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
Tone
How to read this claim
Kept public as exploratory because it indirect comparison; mixed endpoint quality; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.
Source Studies (2)
Self‐applied topical interventions for melasma: a systematic review and meta‐analysis of data from randomized, investigator‐blinded clinical trials
randomized, split-face