Self‐applied topical interventions for melasma: a systematic review and meta‐analysis of data from randomized, investigator‐blinded clinical trials
randomized, split-face
EVIDENCE COMPARISON
DirectionalLignin Peroxidase
vs Tranexamic Acid
for Pigmentation Reduction
Early or indirect evidence suggests lignin peroxidase and tranexamic acid show equal performance for reducing pigmentation to improve skin tone, based on indirect comparison.
1.00x
Effect ratio
Neither
Favored
9
Studies
Indirect
Comparison
ExploratoryMixed endpointsTone
Limits: Indirect comparison · Mixed endpoint quality · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; mixed endpoint quality; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.
1 linked trialIngredient trial
Source Studies (9)
The effectiveness and safety of 3% tranexamic acid cream vs. 4% hydroquinone cream for mixed-type melasma in skin of color: a double-blind, split-face, randomized controlled trial.
randomized, double-blind, split-face
… and efficacy of niosomal and conventional tranexamic acid/niacinamide vs. hydroquinone creams in melasma: A randomized, double-blind, case-controlled clinical …
randomized, double-blind
Comparison of the Efficacy of Intralesional Tranexamic Acid Versus Topical 4% Hydroquinone in Treating Melasma.
controlled
Microneedling-assisted topical tranexamic acid solution versus 4% hydroquinone for treating melasma: A split-face randomized study.
controlled
Intradermal Injection of 100mg Tranexamic Acid Versus Topical 4% Hydroquinone for the Treatment of Melasma: A Randomized, Controlled Trial.
controlled
The effectiveness and safety of 3% tranexamic acid cream vs. 4% hydroquinone cream for mixed-type melasma in skin of color: a double-blind, split-face, randomized controlled trial.
randomized, double-blind, split-face
Fractional erbium:YAG laser (2940 nm) plus topical hydroquinone compared to intradermal tranexamic acid plus topical hydroquinone for the treatment of refractory melasma: a randomized controlled trial.
controlled
A randomized and placebo-controlled study to compare the skin-lightening efficacy and safety of lignin peroxidase cream vs. 2% hydroquinone cream.
randomized, double-blind