A Randomized, Double-Blind, Split-Face Study of Topical Silymarin vs 2% Hydroquinone Cream in Melasmas.
randomized, double-blind, split-face
EVIDENCE COMPARISON
DirectionalLignin Peroxidase
vs Silymarin
for Pigmentation Reduction
Early or indirect evidence suggests lignin peroxidase reduces pigmentation 1.70x more effectively than silymarin for improving skin tone, based on indirect comparison.
1.70x
Effect ratio
Lignin Peroxidase
Favored
3
Studies
Indirect
Comparison
ExploratoryMixed endpointsTone
Limits: Indirect comparison · Mixed endpoint quality · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; mixed endpoint quality; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.
1 linked trialIngredient trial
Source Studies (3)
A Randomized, Double-Blind, Split-Face Study of Topical Silymarin vs 2% Hydroquinone Cream in Melasmas.
randomized, double-blind, split-face
A randomized and placebo-controlled study to compare the skin-lightening efficacy and safety of lignin peroxidase cream vs. 2% hydroquinone cream.
randomized, double-blind