Role of Antioxidants in Melasma: A Systematic Review
randomized, double-blind
EVIDENCE COMPARISON
DirectionalLignin Peroxidase
vs Cysteamine
for Pigmentation Reduction
Early or indirect evidence suggests lignin peroxidase and cysteamine show equal performance for reducing pigmentation to improve skin tone, based on indirect comparison.
1.00x
Effect ratio
Neither
Favored
2
Studies
Indirect
Comparison
ExploratoryEstimated endpointTone
Limits: Indirect comparison · Includes estimated measurement · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; includes estimated measurement; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.