Ketoconazole vs Permethrin 5% for Redness Reduction

doi:10.1159/000065849

EVIDENCE COMPARISON

Directional

Ketoconazole
vs Permethrin 5%
for Redness Reduction

Early or indirect evidence suggests ketoconazole may reduce redness 1.17 times more effectively than permethrin 5% for improving skin tone, based on indirect comparison.

1.17x

Effect ratio

Ketoconazole

Favored

Studies

Indirect

Comparison

ExploratorySubjective endpointTone

Limits: Indirect comparison · Includes subjective endpoint · Early-stage evidence tier

This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.

How to read this claim

Kept public as exploratory because it indirect comparison; includes subjective endpoint; early-stage evidence tier.

Some study-specific context may affect how broadly this comparison generalizes.

Source Studies (2)

Permethrin 5% cream versus metronidazole 0.75% gel for the treatment of papulopustular rosacea. A randomized double-blind placebo-controlled study.

controlled

DOI PubMed

Metronidazole 0.75% gel vs. ketoconazole 2% cream in the treatment of facial seborrheic dermatitis: a randomized, double-blind study.

randomized, double-blind