A Randomized, Double-Blind, Split-Face Study of Topical Silymarin vs 2% Hydroquinone Cream in Melasmas.
randomized, double-blind, split-face
EVIDENCE COMPARISON
Gold StandardHydroquinone
vs Silymarin
for Pigmentation Reduction
Studies show hydroquinone reduces pigmentation 1.70 times more effectively than silymarin for improving skin tone.
1.70x
Effect ratio
Hydroquinone
Favored
2
Studies
Direct
Comparison
Tone
How to read this claim
Direct comparison with enough study context for public-facing comparative wording, with limits noted for mixed endpoint quality.
The published evidence does not currently show a major generalization warning beyond the listed study limits.
1 linked trialIngredient trial