Role of Antioxidants in Melasma: A Systematic Review
randomized, double-blind
EVIDENCE COMPARISON
Gold StandardEarly or indirect evidence suggests hydroquinone and cysteamine demonstrate equal effectiveness for reducing pigmentation and improving skin tone.
Effect ratio
Favored
Study
Comparison
Tone
Kept public as exploratory because it includes estimated measurement.
Some study-specific context may affect how broadly this comparison generalizes.