Sequential therapy with topical clobetasol for 14 days followed by hydroquinone versus hydroquinone alone in facial melasma treatment: a randomized, double-blind, controlled clinical trial.
controlled
EVIDENCE COMPARISON
DirectionalHydroquinone
vs Clobetasol
for Pigmentation Reduction
Early or indirect evidence suggests hydroquinone and clobetasol show similar effectiveness for improving skin tone through pigmentation reduction.
1.00x
Effect ratio
Neither
Favored
1
Study
Direct
Comparison
ExploratorySubjective endpointTone
Limits: Includes subjective endpoint · Early-stage evidence tier
How to read this claim
Kept public as exploratory because it includes subjective endpoint; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.