… double-blind, placebo-controlled clinical trial evaluating the efficacy of a novel combination of hyaluronic acid serum and antioxidant cream for rejuvenation of the …
randomized, double-blind
EVIDENCE COMPARISON
SupportiveHyaluronic Acid Matrix (HAm)
vs Silymarin
for Pigmentation Reduction
Early or indirect evidence suggests hyaluronic acid matrix reduces pigmentation 1.33 times more effectively than silymarin for improving skin tone, based on indirect comparison.
1.33x
Effect ratio
Hyaluronic Acid Matrix (HAm)
Favored
2
Studies
Indirect
Comparison
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
Tone
How to read this claim
Kept public as exploratory because it indirect comparison; includes estimated measurement.
Some study-specific context may affect how broadly this comparison generalizes.
Source Studies (2)
Melasma update
randomized, double-blind, split-face