… a New Hyaluronic Acid Matrix Ingredient Improves Skin Brightness, Hydration, Smoothness, and Roughness: Results from a Randomized, Double-Blinded, Placebo …
randomized, double-blind
EVIDENCE COMPARISON
DirectionalHyaluronic Acid Matrix (HAm)
vs Melatonin
for Wrinkle Reduction
Early or indirect evidence suggests melatonin may reduce wrinkles 1.27 times more effectively than hyaluronic acid matrix for skin firmness, based on indirect comparison.
1.27x
Effect ratio
Melatonin
Favored
2
Studies
Indirect
Comparison
ExploratoryEstimated endpointFirmness
Limits: Indirect comparison · Includes estimated measurement · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; includes estimated measurement; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.