… a New Hyaluronic Acid Matrix Ingredient Improves Skin Brightness, Hydration, Smoothness, and Roughness: Results from a Randomized, Double-Blinded, Placebo …
randomized, double-blind
EVIDENCE COMPARISON
DirectionalHyaluronic Acid Matrix (HAm)
vs Melatonin
for Surface Smoothness
Early or indirect evidence suggests melatonin may provide 10% better skin texture smoothness than hyaluronic acid matrix, based on indirect comparison.
1.10x
Effect ratio
Melatonin
Favored
3
Studies
Indirect
Comparison
ExploratoryEstimated endpointTexture
Limits: Indirect comparison · Includes estimated measurement · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; includes estimated measurement; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.
Source Studies (3)
… double-blind, placebo-controlled clinical trial evaluating the efficacy of a novel combination of hyaluronic acid serum and antioxidant cream for rejuvenation of the …
randomized, double-blind
Antiaging efficacy of melatonin-based day and night creams: A randomized, split-face, assessor-blinded proof-of-concept trial
randomized, split-face