… a New Hyaluronic Acid Matrix Ingredient Improves Skin Brightness, Hydration, Smoothness, and Roughness: Results from a Randomized, Double-Blinded, Placebo …
randomized, double-blind
EVIDENCE COMPARISON
DirectionalHyaluronic Acid Matrix (HAm)
vs Melatonin
for Hydration Retention
Early or indirect evidence suggests hyaluronic acid matrix retains 1.65 times more skin moisture than melatonin, based on indirect comparison.
1.65x
Effect ratio
Hyaluronic Acid Matrix (HAm)
Favored
2
Studies
Indirect
Comparison
ExploratoryMixed endpointsMoisture
Limits: Indirect comparison · Mixed endpoint quality · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; mixed endpoint quality; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.