… double-blind, placebo-controlled clinical trial evaluating the efficacy of a novel combination of hyaluronic acid serum and antioxidant cream for rejuvenation of the …
randomized, double-blind
EVIDENCE COMPARISON
DirectionalHyaluronic Acid Matrix (HAm)
vs Melatonin
for Elasticity Improvement
Early or indirect evidence suggests melatonin may improve skin firmness elasticity 1.15 times more than hyaluronic acid matrix, based on indirect comparison.
1.15x
Effect ratio
Melatonin
Favored
2
Studies
Indirect
Comparison
ExploratoryMixed endpointsFirmness
Limits: Indirect comparison · Mixed endpoint quality · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; mixed endpoint quality; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.