A double-blind, placebo controlled clinical trial evaluating the efficacy and safety of a new skin whitening combination in patients with chloasma
double-blind, split-face
EVIDENCE COMPARISON
DirectionalHyaluronic Acid Matrix (HAm)
vs Lipo-hydroxy Acid
for Pigmentation Reduction
Early or indirect evidence suggests hyaluronic acid matrix may reduce pigmentation twice as effectively as lipo-hydroxy acid for improving skin tone, based on indirect comparison.
2.00x
Effect ratio
Hyaluronic Acid Matrix (HAm)
Favored
2
Studies
Indirect
Comparison
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
Tone
How to read this claim
Kept public as exploratory because it indirect comparison; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.
Source Studies (2)
… double-blind, placebo-controlled clinical trial evaluating the efficacy of a novel combination of hyaluronic acid serum and antioxidant cream for rejuvenation of the …
randomized, double-blind