A Randomized, Double-Blind, Placebo-Controlled, Split-Face Study of the Efficacy of Topical Epidermal Growth Factor for the Treatment of Melasma.
randomized, double-blind, split-face
EVIDENCE COMPARISON
SupportiveHyaluronic Acid Matrix (HAm)
vs Epidermal Growth Factor (EGF)
for Pigmentation Reduction
Early or indirect evidence suggests hyaluronic acid matrix reduces pigmentation 3.73 times more effectively than epidermal growth factor for skin tone improvement, based on indirect comparison.
3.73x
Effect ratio
Hyaluronic Acid Matrix (HAm)
Favored
2
Studies
Indirect
Comparison
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
Tone
How to read this claim
Kept public as exploratory because it indirect comparison; mixed endpoint quality.
Some study-specific context may affect how broadly this comparison generalizes.
Source Studies (2)
… double-blind, placebo-controlled clinical trial evaluating the efficacy of a novel combination of hyaluronic acid serum and antioxidant cream for rejuvenation of the …
randomized, double-blind