Comparing the efficacy of Myjet‐assisted tranexamic acid and vitamin C in treating melasma: A split‐face controlled trial
randomized, double-blind, split-face
EVIDENCE COMPARISON
DirectionalGlycolic Acid
vs Tranexamic Acid
for Pigmentation Reduction
Early or indirect evidence suggests tranexamic acid may reduce pigmentation nearly three times more effectively than glycolic acid for evening skin tone, based on indirect comparison.
2.75x
Effect ratio
Tranexamic Acid
Favored
4
Studies
Indirect
Comparison
ExploratorySubjective endpointTone
Limits: Indirect comparison · Includes subjective endpoint · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; includes subjective endpoint; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.
Source Studies (4)
Topical Tranexamic Acid Versus Topical Vitamin C With Microneedling in Periorbital Hyperpigmentation; Comparative Study
controlledn=60
Fractional carbon dioxide laser assisted delivery of tranexamic acid versus ascorbic acid in the treatment of melasma: a split face comparative study with digital skin analysis.
controlled
Clinical efficacy and safety of 20% glycolic peel, 15% lactic peel, and topical 20% vitamin C in constitutional type of periorbital melanosis: a comparative study.
randomized