A Randomized, Double-Blind, Placebo-Controlled, Split-Face Study of the Efficacy of Topical Epidermal Growth Factor for the Treatment of Melasma.
randomized, double-blind, split-face
EVIDENCE COMPARISON
SupportiveEpidermal Growth Factor (EGF)
vs Silymarin
for Pigmentation Reduction
Early or indirect evidence suggests silymarin may reduce pigmentation nearly three times more effectively than epidermal growth factor for improving skin tone, based on indirect comparison.
2.80x
Effect ratio
Silymarin
Favored
2
Studies
Indirect
Comparison
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
Tone
How to read this claim
Kept public as exploratory because it indirect comparison; includes estimated measurement.
Some study-specific context may affect how broadly this comparison generalizes.
Source Studies (2)
Melasma update
randomized, double-blind, split-face