A double-blind, placebo controlled clinical trial evaluating the efficacy and safety of a new skin whitening combination in patients with chloasma
double-blind, split-face
EVIDENCE COMPARISON
DirectionalEpidermal Growth Factor (EGF)
vs Lipo-hydroxy Acid
for Pigmentation Reduction
Early or indirect evidence suggests lipo-hydroxy acid reduces pigmentation for improved skin tone 1.87 times more effectively than epidermal growth factor, based on indirect comparison.
1.87x
Effect ratio
Lipo-hydroxy Acid
Favored
2
Studies
Indirect
Comparison
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
Tone
How to read this claim
Kept public as exploratory because it indirect comparison; mixed endpoint quality; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.
Source Studies (2)
A Randomized, Double-Blind, Placebo-Controlled, Split-Face Study of the Efficacy of Topical Epidermal Growth Factor for the Treatment of Melasma.
randomized, double-blind, split-face