Efficacy and safety of topical delgocitinib cream versus oral alitretinoin capsules in adults with severe chronic hand eczema (DELTA FORCE): a 24-week, randomised, head-to-head, phase 3 trial.
controlled
EVIDENCE COMPARISON
DirectionalDelgocitinib
vs Alitretinoin
for Barrier Integrity
Early or indirect evidence suggests delgocitinib may improve skin barrier integrity 1.31 times more effectively than alitretinoin for enhancing moisture retention.
1.31x
Effect ratio
Delgocitinib
Favored
1
Study
Direct
Comparison
ExploratorySubjective endpointMoisture
Limits: Includes subjective endpoint · Early-stage evidence tier
How to read this claim
Kept public as exploratory because it includes subjective endpoint; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.