A Randomized, Double-Blind, Split-Face Study of Topical Silymarin vs 2% Hydroquinone Cream in Melasmas.
randomized, double-blind, split-face
EVIDENCE COMPARISON
SupportiveCysteamine
vs Silymarin
for Pigmentation Reduction
Early or indirect evidence suggests silymarin may provide slightly better pigmentation reduction for skin tone improvement than cysteamine, based on indirect comparison.
1.06x
Effect ratio
Silymarin
Favored
3
Studies
Indirect
Comparison
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
Tone
How to read this claim
Kept public as exploratory because it indirect comparison; includes estimated measurement.
Some study-specific context may affect how broadly this comparison generalizes.
1 linked trialIngredient trial