A Randomized, Double-Blind, Split-Face Study of Topical Silymarin vs 2% Hydroquinone Cream in Melasmas.
randomized, double-blind, split-face
EVIDENCE COMPARISON
DirectionalClobetasol
vs Silymarin
for Pigmentation Reduction
Early or indirect evidence suggests clobetasol may reduce pigmentation 1.7 times more effectively than silymarin for improving skin tone, based on indirect comparison.
1.70x
Effect ratio
Clobetasol
Favored
3
Studies
Indirect
Comparison
ExploratoryMixed endpointsTone
Limits: Indirect comparison · Mixed endpoint quality · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; mixed endpoint quality; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.
1 linked trialIngredient trial
Source Studies (3)
A Randomized, Double-Blind, Split-Face Study of Topical Silymarin vs 2% Hydroquinone Cream in Melasmas.
randomized, double-blind, split-face
Sequential therapy with topical clobetasol for 14 days followed by hydroquinone versus hydroquinone alone in facial melasma treatment: a randomized, double-blind, controlled clinical trial.
controlled