Efficacy and safety of calcipotriol as a potential topical treatment of acne vulgaris: a randomized, controlled, triple blinded, split-face clinical trial
randomized, split-face
EVIDENCE COMPARISON
DirectionalCalcipotriol (Vitamin D Analogue)
vs Trifarotene
for Tone Evenness
Early or indirect evidence suggests calcipotriol may improve skin tone evenness 1.28 times more effectively than trifarotene, based on indirect comparison.
1.28x
Effect ratio
Calcipotriol (Vitamin D Analogue)
Favored
1
Study
Indirect
Comparison
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
Tone
How to read this claim
Kept public as exploratory because it indirect comparison; includes subjective endpoint; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.