Efficacy and safety of calcipotriol as a potential topical treatment of acne vulgaris: a randomized, controlled, triple blinded, split-face clinical trial
randomized, split-face
EVIDENCE COMPARISON
DirectionalCalcipotriol (Vitamin D Analogue)
vs Trifarotene
for Redness Reduction
Early or indirect evidence suggests calcipotriol may reduce skin redness 1.27 times more effectively than trifarotene for improving skin tone, based on indirect comparison.
1.27x
Effect ratio
Calcipotriol (Vitamin D Analogue)
Favored
1
Study
Indirect
Comparison
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
Tone
How to read this claim
Kept public as exploratory because it indirect comparison; includes subjective endpoint; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.