Clinical, dermoscopic, and histopathologic evaluation of topical methotrexate 1% hydrogel versus topical Calcipotriol 0.005% cream in the treatment of plaque psoriasis.
controlled
EVIDENCE COMPARISON
DirectionalCalcipotriol (Vitamin D Analogue)
vs Topical Methotrexate
for Surface Smoothness
Early or indirect evidence suggests calcipotriol improves skin surface smoothness 4.29 times more effectively than topical methotrexate for texture enhancement.
4.29x
Effect ratio
Calcipotriol (Vitamin D Analogue)
Favored
1
Study
Direct
Comparison
ExploratorySubjective endpointTexture
Limits: Includes subjective endpoint · Early-stage evidence tier
How to read this claim
Kept public as exploratory because it includes subjective endpoint; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.