Clinical, dermoscopic, and histopathologic evaluation of topical methotrexate 1% hydrogel versus topical Calcipotriol 0.005% cream in the treatment of plaque psoriasis.
controlled
EVIDENCE COMPARISON
DirectionalCalcipotriol (Vitamin D Analogue)
vs Topical Methotrexate
for Redness Reduction
Early or indirect evidence suggests calcipotriol reduces redness three times more effectively than topical methotrexate for improving skin tone.
3.00x
Effect ratio
Calcipotriol (Vitamin D Analogue)
Favored
1
Study
Direct
Comparison
ExploratorySubjective endpointTone
Limits: Includes subjective endpoint · Early-stage evidence tier
How to read this claim
Kept public as exploratory because it includes subjective endpoint; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.