2% supramolecular salicylic acid hydrogel vs. adapaline gel in mild to moderate acne vulgaris treatment: A multicenter, randomized, evaluator-blind, parallel-controlled trial.
randomized
EVIDENCE COMPARISON
DirectionalEarly or indirect evidence suggests benzoyl peroxide provides 1.76 times better pore refinement for skin texture than salicylic acid, based on indirect comparison.
Effect ratio
Favored
Studies
Comparison
Limits: Indirect comparison · Includes estimated measurement · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
Kept public as exploratory because it indirect comparison; includes estimated measurement; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.