Efficacy and safety of topical delgocitinib cream versus oral alitretinoin capsules in adults with severe chronic hand eczema (DELTA FORCE): a 24-week, randomised, head-to-head, phase 3 trial.
controlled
EVIDENCE COMPARISON
DirectionalAlitretinoin
vs Dupilumab
for Barrier Integrity
Early or indirect evidence suggests dupilumab may provide 9% better moisture barrier integrity compared to alitretinoin, based on indirect comparison.
1.09x
Effect ratio
Dupilumab
Favored
2
Studies
Indirect
Comparison
ExploratorySubjective endpointMoisture
Limits: Indirect comparison · Includes subjective endpoint · Early-stage evidence tier
This is an indirect comparison — the two ingredients were not tested head-to-head in the same trial. The ratio is derived from separate studies against a common comparator.
How to read this claim
Kept public as exploratory because it indirect comparison; includes subjective endpoint; early-stage evidence tier.
Some study-specific context may affect how broadly this comparison generalizes.